Cefuroxime Side Effects, Dosage, Uses & More

Cefuroxime | Side Effects, Dosage, Uses & More

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Cefuroxime | Side Effects, Dosage, Uses & More

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Highlights for cefuroxime

Both a generic version and a brand-name version of the cefuroxime oral tablet are now on the market. Ceftin is the name of the brand.

Cefuroxime also comes as a liquid solution. Oral consumption is required for either the tablet or the suspension.

A tablet form of cefuroxime is taken orally to treat a variety of infections brought on by bacteria. Pharyngitis, otitis media, sinusitis, and bronchitis are some of the infections that fall within this category.

Cefuroxime side effects

The oral tablet form of cefuroxime does not cause drowsiness, but it has the potential to produce additional adverse effects.

More common side effects

The following is a list of the more common adverse effects that may occur as a result of using cefuroxime oral tablet:

The Jarisch-Herxheimer reaction manifests itself with diarrhoea, nausea, and vomiting. After receiving antibiotic treatment for a condition, some patients may experience this transient reaction. The symptoms may include a high temperature, chills, or soreness in the muscles.

In the event that these side effects are not severe, it is possible that they will disappear in a matter of days or weeks. Talk to your healthcare provider or pharmacist if the symptoms become more severe or if they do not go away.

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Serious adverse effects may result.

If you are experiencing major adverse effects, you should contact your physician as soon as possible. In the event that your symptoms appear to be life-threatening or if you believe you may be experiencing a medical emergency, dial 911 immediately. The following is a list of potentially serious side effects and the symptoms they cause:

Reactions caused by allergies. Hives are one of the possible symptoms.

symptoms including difficulty breathing, swelling of the cheeks, lips, tongue, or throat

Please understand that our intention is to present you with the most recent and pertinent information possible. However, due to the fact that medications have varying effects on different people, we are unable to guarantee that this material covers all of the potential adverse effects. This information is not intended to replace professional medical advice in any way. Always have a conversation about the potential for adverse effects with a healthcare provider who is familiar with your medical history.

Warnings of vital importance

Intolerance to other drugs that are in the same class as cefuroxime: You should not take cefuroxime if you have ever had an adverse reaction to other drugs that are in the same class as cefuroxime. An allergic reaction has the potential to be life-threatening, and in the most extreme situations, it can even be fatal (cause death). Have a conversation with your primary care physician to determine whether or not you are at risk of experiencing an allergic reaction.

Clostridium difficile-associated diarrhoea: Diarrhea can be brought on by taking excessive amounts of cefuroxime or using this medication for a period of more than 14 days. The infectious bacteria known as Clostridium difficile is to blame for this diarrhoea. The diarrhoea is often mild to moderate in severity most of the time. In extremely unusual instances, it might result in life-threatening inflammation of the colon (large intestine).

Phenylketonuria: Phenylalanine can be found in the oral suspension version of the antibiotic cefuroxime. This is a naturally occurring amino acid that can be found in a wide variety of foods, including eggs and meat. If you have phenylketonuria, you should steer clear of using this medication. When this disease is present, the body is unable to break down the amino acid phenylalanine.

What does cefuroxime stand for?

Ceftin is the brand name of the prescription medication known as cefuroxime oral tablet. This medication is only accessible with a doctor’s prescription. Additionally, it is obtainable in its generic form. The cost of generic medications is typically lower. It’s possible that they won’t be offered in the same dosage strengths or forms as the branded version in some circumstances.

Cefuroxime also comes as a liquid solution. Both formulations are intended to be used orally.

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Why it’s put to use

Cefuroxime is employed in the treatment of a variety of infections brought on by bacteria. Pharyngitis, otitis media, sinusitis, and bronchitis are some of the conditions that fall within this category. In addition, gonorrhoea, impetigo, Lyme disease, and urinary tract infections are included in this category.

The workings of it

The drug cefuroxime is classified as a member of the group of medications known as cephalosporins. A group of different pharmaceuticals that share a common mode of action is referred to as a class of drugs. These medications are frequently prescribed to address illnesses that are analogous to one another.

Cefuroxime is effective because it prevents the formation of bacterial cell walls, which is necessary for their growth. Because of this, the cell membranes become compromised (break). The germs perish as a direct consequence of this action.

There is a possibility that cefuroxime will interact with other drugs.

There is a possibility of drug interactions when you use cefuroxime oral tablet along with other drugs, vitamins, or herbs. When one substance alters the functioning of another, this is known as an interaction. This may result in adverse effects or reduce the efficacy of the medication.

Your physician ought to properly manage all of your prescriptions for you in order to help you avoid interactions. It is imperative that you discuss any drugs, supplements, or herbs that you are currently taking with your primary care physician. Talk to your healthcare provider or pharmacist if you have any questions about how this medication might interact with other medications that you are currently taking.

The following is a list of examples of medications that may produce adverse reactions when used with cefuroxime.

Oral contraceptives

Oral contraceptives, also known as birth control pills, may not be absorbed as well by the body if they are taken alongside cefuroxime. Because of this, it’s possible that they won’t be as effective. During the time that you are being treated with cefuroxime, your physician could recommend that you switch to a different type of birth control. Some examples of these medications are as follows:

drospirenone/ethyinyl estradiol levonorgestrel/ethinyl estradiol norethindrone acetate/ethinyl estradiol desogestrel/ethinyl estradiol norgestrel/ethinyl estradiol

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Stomach acid medications

Cefuroxime may not be absorbed as efficiently by the body if it is combined with certain medications that lower the amount of acid produced by the stomach. This indicates that it might not work as well as before. Some examples of these medications are as follows:

antacids, such as: calcium carbonate magnesium hydroxide aluminium hydroxide

H2-antagonists, such famotidine and cimetidine; proton pump inhibitors, like lansoprazole; and other similar medications

omeprazole \spantoprazole

It is best to take cefuroxime at least an hour before taking antacids, or wait at least two hours after taking them. During treatment with cefuroxime, you should avoid taking any medications that contain H2-antagonists or proton pump inhibitors.

Other medications

Gout and kidney stones are just two of the illnesses that can be treated successfully with probenecid. Combining probenecid and cefuroxime use results in a higher overall concentration of cefuroxime in the body. This increases the likelihood that you will experience side effects. If you take both of these medications at the same time, your primary care physician would probably monitor you closely for any adverse reactions to cefuroxime.

Cefuroxime warnings

This medication comes with a number of precautions.

Caution: allergens present

Cefuroxime has been linked to life-threatening allergic reactions in certain people. Symptoms may include the following:

symptoms including itching and swelling, including but not limited to the face, lips, tongue, and throat

In the event that you have an allergic reaction, you should contact either your physician or the local poison control centre as soon as possible. If your symptoms are severe, you should phone 911 or go to the emergency room that is located closest to you. If you have ever experienced an adverse reaction to this medication in the past, you should avoid taking it again. Taking it once again can prove to be lethal.

Warnings for specific categories of people

Those who have issues with their kidneys should know that cefuroxime is eliminated from the body by the kidneys. It is possible for there to be an accumulation of cefuroxime in the body if the kidneys are not functioning properly. Your physician might recommend that you take cefuroxime less frequently than is customary in order to avoid this problem.

For pregnant women: The FDA has assigned cefuroxime to pregnancy category B. That entails two different things:

In studies conducted on animals, using the medication by a pregnant woman did not pose any danger to the developing baby.

Insufficient research on people has been carried out to determine whether or not the medication poses a threat to the developing foetus.

Talk to your healthcare provider if you are pregnant or if you are considering becoming pregnant. Research conducted on animals may not always accurately predict how people will react. As a result, women who are pregnant shouldn’t use this medication unless it’s really necessary.

If you become pregnant while using this medication, you should contact your doctor immediately.

Warning for mothers who are nursing their children: Cefuroxime is excreted into breast milk and may make a kid more susceptible to the drug’s adverse effects. If you are breastfeeding your infant, be sure to let your doctor know. It is possible that you will need to make a choice between discontinuing nursing and terminating treatment with this medicine.

Regarding senior citizens: The kidneys of elderly people may not function as well as they once did. This may result in a decreased rate of medication elimination from your body. As a consequence of this, a greater quantity of a drug is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects.

In the case of children, Cefuroxime should not be administered to infants younger than three months of age.

How to properly administer cefuroxime

This dosing information pertains to the oral tablet version of cefuroxime. It’s conceivable that not all dosing options or drug formulations have been included here. The following factors will determine the optimal dosage, medicine form, and administration schedule for the medication:

your age, the ailment being treated, the severity of your condition, and any other medical issues you have other medical disorders you have your response to the initial dose to consider.

Structures and capabilities

Generic: Cefuroxime

Tablets to be taken orally.

Strengths: 125 mg, 250 mg, 500 mg

Manufacturer: Ceftin

Tablets to be taken orally.

Strengths: 250 mg, 500 mg

Pharyngitis and tonsillitis medication dosage (mild to moderate)

Dosage for adults (those 18 years old and older):

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for adolescents (13 to 17 years old):

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

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Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning.

A lower value indicates that the kidneys are functioning less effectively.

For seniors (defined as individuals aged 65 and older): The kidneys of older folks may not function as well as they did in the past. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

Warnings

Tablets and suspension of cefuroxime cannot be substituted for one another on a milligram-per-milligram basis. (What this indicates is that you cannot replace one with the other in equal amounts.)

Instead of the cefuroxime tablets, the suspension should be given to children who are unable to swallow the tablets. Do not offer them a tablet that has been crushed. When the tablet is crushed, a powerful and lingering taste of bitterness is released.

Dosage for acute cases of middle ear infection

Dosage for adolescents (14 to 17 years old):

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for children (ages 3 months to 13 years old) who are able to take tablets in their entirety:

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

People who are undergoing hemodialysis need to have a single additional standard dose administered at the conclusion of each and every dialysis session.

Warnings

Tablets and suspension of cefuroxime cannot be substituted for one another on a milligram-per-milligram basis. (What this indicates is that you cannot replace one with the other in equal amounts.)

Instead of the cefuroxime tablets, the suspension should be given to children who are unable to swallow the tablets. Do not offer them a tablet that has been crushed. When the tablet is crushed, a powerful and lingering taste of bitterness is released.

What dose should be taken for acute sinusitis? (mild to moderate)

Dosage for adults (those 18 years old and older):

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for adolescents (those between the ages of 13 and 17):

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

The recommended dose is 250 milligrammes to be taken every 12 hours for a period of 10 days.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

Warnings

Tablets and suspension of cefuroxime cannot be substituted for one another on a milligram-per-milligram basis. (What this indicates is that you cannot replace one with the other in equal amounts.)

Instead of the cefuroxime tablets, the suspension should be given to children who are unable to swallow the tablets. Do not offer them a tablet that has been crushed. When the tablet is crushed, a powerful and lingering taste of bitterness is released.

What dose should I take for my acute bronchitis? (mild to moderate)

Acute bronchitis, also known as mild to moderate bronchitis:

Dosage for adults (those aged 18 and older) is typically 250 or 500 mg every 12 hours for a period of 10 days.

Dosage for children (ages 13 to 17 years old): The recommended dosage is 250 or 500 mg every 12 hours for a period of 10 days.

Dosage for children (ages 0 to 12 years old who are able to swallow tablets in their entirety): It is not recommended that this medication be given to children younger than 13 years old who have this condition.

Acute bronchitis can lead to a secondary infection, which can range from mild to moderate severity.

Dosage for adults (those aged 18 and older) The average adult dosage is 250 or 500 mg every 12 hours for 5–10 days.

Dosage for adolescents (those between the ages of 13 and 17 years old): The average dosage is 250 or 500 mg every 12 hours for 5–10 days.

Dosage for children (ages 3 months to 12 years old who are able to swallow tablets in their entirety): The normal dose is 250 mg twice day for a period of 10 days.

Dosage for children (ages 0 to 2 months): Cefuroxime should not be administered to infants or children with an age less than 3 months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

For seniors (those aged 65 and up), the following is recommended: It’s possible that kidney function declines with age, particularly in elderly persons. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

Dosage for infections of the skin or below the skin that are not particularly complicated

Dosage for adults (those 18 years old and older):

The recommended dose is either 250 or 500 milligrammes every 12 hours for a period of 10 days.

Dosage for adolescents (those between the ages of 13 and 17):

The recommended dose is either 250 or 500 milligrammes every 12 hours for a period of 10 days.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

In children younger than 13 years old, it is not recommended that they take this drug to treat the illness.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

For seniors (those aged 65 and up), the following is recommended: It’s possible that kidney function declines with age, particularly in elderly persons. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

dosage for urinary tract infections that are not particularly problematic

Dosage for adults (those 18 years old and older):

The usual dose is 250 milligrammes once every 12 hours for seven to ten days.

Dosage for adolescents (those between the ages of 13 and 17):

The usual dose is 250 milligrammes once every 12 hours for seven to ten days.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

There is no information available on dosage. It is not common for children of this age range to suffer from this illness.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

For seniors (those aged 65 and up), the following is recommended: It’s possible that kidney function declines with age, particularly in elderly persons. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

For cases of gonorrhoea that are not difficult

Dosage for adults (those 18 years old and older):

A single dose of 1,000 milligrammes is the standard recommendation.

Dosage for adolescents (13 to 17 years old):

A single dose of 1,000 milligrammes is the standard recommendation.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

There is no information available on dosage. It is not common for children of this age range to suffer from this illness.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

For seniors (those aged 65 and up), the following is recommended: It’s possible that kidney function declines with age, particularly in elderly persons. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

In the early stages of Lyme illness

Dosage for adults (those 18 years old and older):

The recommended dose is 500 milligrammes (mg) every 12 hours for a period of 20 days.

Dosage for adolescents (13 to 17 years old):

The recommended dose is 500 milligrammes (mg) every 12 hours for a period of 20 days.

Dosage for children (ages 3 months to 12 years old) who are able to take tablets in their entirety:

In children younger than 13 years old, it is not recommended that they take this drug to treat the illness.

Dosage for infants and young children (ages 0 to 2 months):

Cefuroxime should not be given to infants who have not yet reached the age of three months.

Special considerations

If you have a creatinine clearance of less than 30 mL/min, your dosage of cefuroxime may need to be modified. This is important information for patients who suffer from kidney disease. The amount of creatinine that is cleared from your blood is a good indicator of how well your kidneys are functioning. A lower value indicates that the kidneys are functioning less effectively.

For seniors (defined as individuals aged 65 and older): The kidneys of older folks may not function as well as they did in the past. Because of this, the body may metabolise medications more slowly as a result. As a consequence of this, a greater quantity of a medicine is retained in your body for a longer period of time. This increases the likelihood that you will experience side effects. It’s possible that your primary care physician will start you out on a lower dose or a different dosing regimen. This can help prevent dangerously high quantities of this substance from developing inside of your body in the first place.

Please understand that our intention is to present you with the most recent and pertinent information possible. However, due to the fact that medications have varying effects on various people, we are unable to guarantee that this list contains all of the possible dosages. This information is not intended to replace professional medical advice in any way. Always with your primary care physician or a pharmacist on the dosages that are appropriate for you.

Take as directed

Cefuroxime oral tablet is used for short-term therapy. It should only be used to treat bacterial infections. It should not be used for viruses such as the common cold. Cefuroxime comes with dangers if you don’t take medication as advised.

If you stop taking the drug suddenly or don’t take it at all: Your infection may remain or get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to perform successfully, a specific amount needs to be in your body at all times.

If you take too much: You could have harmful quantities of the substance in your body. Symptoms of an overdose of this substance can include rapid, uneven movements of any limb or region of the body. If you think you’ve taken too much of this drug, call your doctor or local poison control centre. If your symptoms are severe, call 911 or go to the nearest emergency room straight soon.

What to do if you miss a dosage: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in serious negative effects.

How to detect if the medicine is working: You should notice a decrease in your symptoms. Your infection should recover.

Important considerations for taking cefuroxime

Keep these things in mind if your doctor recommends cefuroxime oral tablet for you.

General

Take this medicine at the time(s) suggested by your doctor.

Cefuroxime oral pill may be taken with or without food.

Cefuroxime oral tablet should not be chopped or crushed.

Storage

Store cefuroxime tablets at a temperature between 59°F and 86°F (15°C and 30°C).

Don’t store this medication in wet or damp environments, such as bathrooms.

Refills

A prescription for this drug is refillable. You should not need a new prescription for this medicine to be renewed. Your doctor will write the number of refills approved on your prescription.

Travel

When travelling with your medication:

Always carry your medication with you. When flying, never put anything into a checked bag. Keep it in your carry-on bag.

Don’t worry about airport X-ray machines. They can’t damage your medication.

You may need to show airport employees the pharmacy label for your prescription. Always carry the original prescription-labeled box with you.

Don’t put this medication in your car’s glove compartment or leave it in the car. Be mindful to avoid doing this when the weather is either hot or very cold.

Clinical monitoring

Your doctor may undertake blood tests to monitor your kidney function before prescribing cefuroxime and during your treatment with this drug. If your kidneys aren’t working well, your doctor may recommend that you take cefuroxime less often.

Hidden expenses

You may need to have blood tests during your therapy with cefuroxime. The cost of these tests will depend on your insurance coverage.

Are there any alternatives?

There are alternative medications available to treat your illness. Some may be better suited for you than others. Talk to your doctor about different medicine options that may work for you.

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