Promethazine HCL - Uses, Side Effects, and More

Promethazine HCL – Uses, Side Effects, and More

Promethazine HCL – Uses, Side Effects, and More

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Please also see the section labeled Warning. Nausea and vomiting that might occur as a result of certain situations (such as before and after surgery, as well as motion sickness) can be prevented and treated using promethazine. Additionally, it is utilized in the treatment of allergy symptoms like rashes, itching, and runny noses. It may be used to make you feel tired or calm before and after surgery, or it may be used to enhance the effectiveness of certain opioid pain medications (such as meperidine).

It is also possible to use it for a limited amount of time as a treatment for a runny nose caused by the common cold. Antihistamines like promethazine operate by inhibiting the production of histamine, a naturally occurring chemical that is produced by your body whenever it experiences an allergic reaction. Its additional effects, such as anti-nausea, relaxation, and pain reduction, may function through altering other naturally occurring molecules, such as acetylcholine, and by acting directly on certain areas of the brain.

Other natural compounds may also be involved. Products marketed toward children younger than 6 years old have not been shown to be either safe or effective in clinical trials. If your child is younger than six years old, do not give them this product to treat cold symptoms unless your pediatrician specifically instructs you to do so. When it comes to youngsters younger than 12 years old, the use of certain goods (such as long-acting tablets and capsules, for example) is not advised. Please consult your physician or pharmacist for any information regarding the safe use of your product. These products do not alleviate the symptoms of the common cold or lessen the duration of the illness, and they may produce major adverse effects.

If you carefully follow all of the dosing instructions, the likelihood of experiencing major adverse effects will be reduced. Do not administer any other cough and cold remedies, especially if they include the same or comparable active components (see also Drug Interactions section). Inquire with your family physician or the pharmacist about alternative treatments for cough and cold symptoms, such as increasing your fluid intake, using a humidifier, or applying saline nasal drops or spray.

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Instructions for the usage of Promethazine HCL

Before beginning treatment with promethazine and whenever you get a refill, make sure you carefully read the Patient Information Leaflet, which should be provided by your pharmacist if one is available. If you have any questions, you should consult with either your physician or your pharmacist.

Take this drug by mouth as advised by your physician, usually between two and four times daily. You may take it with or without food. To prevent nausea and vomiting caused by motion sickness, the first dose of promethazine should be taken thirty to sixty minutes before the trip begins. If you want to treat your allergies but don’t want to feel sleepy throughout the day, you can take this prescription just once a day before bed. When used before surgery, promethazine may be taken the night before or just before the procedure, and it may be continued following as indicated. When used after surgery, promethazine may be used as needed.

If you are taking this medication in liquid form, you will need to measure the amount with a special measuring instrument or spoon to ensure accurate dosing. You should not use a regular spoon since you run the risk of not getting the right amount.

Your age, current medical condition, and how well you respond to treatment all play a role in determining the appropriate dosage. When treating youngsters, the dosage may also be determined by the child’s weight. Do not take this drug more frequently or raise your dose without first consulting your doctor.

Side Effects

It is possible for this medication to cause drowsiness, dizziness, constipation, blurred vision, or dry mouth. Please let your doctor know if any of these side effects continue or get worse.

If you suffer from dry mouth, you can alleviate the discomfort by sucking on sugar-free hard candies or ice chips, chewing sugar-free gum, drinking water, or using a saliva substitute.

Keep in mind that the reason your doctor has recommended that you take this medication is that he or she believes that the potential benefits to you outweigh the potential risks of doing so. The majority of persons who take this medicine do not report experiencing any severe adverse effects.

Notify your physician immediately if you experience any serious side effects, including but not limited to: fainting, slow heartbeat, mental or mood changes (such as hallucinations, nervousness, irritability, restlessness, confusion), unusual or uncontrolled movements (such as fixed upward stare, neck twisting, tongue movements), shaking (tremor), difficulty urinating, easy bleeding or bruising, signs of infection (such as fever, persistent sore throat), severe stomach/abdominal pain, persistent nausea.

In the event that you experience any very serious adverse effects, such as shallow or shallower breathing or convulsions, seek immediate medical attention.

This medicine carries a very low risk of causing the neuroleptic malignant syndrome, but there is a chance that it could (NMS). If you develop any of the following symptoms, you should seek immediate medical attention: fever, muscle stiffness/pain/tenderness/weakness, extreme weariness, extreme disorientation, sweating, fast/irregular heartbeat, dark urine, evidence of kidney difficulties (such as a change in the amount of urine).

It is quite unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you observe any symptoms of a major allergic response, such as a rash, itching/swelling (particularly of the face/tongue/throat), severe dizziness, or difficulty breathing. These symptoms include:

This list of potential adverse effects is not exhaustive in any way. Please consult your physician or pharmacist if you have any side effects that are not listed above.

In the United States, if you are experiencing any adverse effects, please consult your primary care physician. You can call the FDA at 1-800-FDA-1088 or visit their website at to report any adverse effects.

In Canada, if you are experiencing any adverse effects, please consult your primary care physician. You can call Health Canada at 1-866-234-2345 to report any adverse effects you experience.

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Inform your physician or pharmacist that you are allergic to promethazine, as well as to any other phenothiazines (such as prochlorperazine), or if you have any additional allergies before beginning treatment with promethazine. There is a possibility that this product contains inactive substances, which, if present, could result in allergic responses or other complications. Discuss the matter further with your pharmacist for further information.

Before beginning treatment with this medication, it is important to discuss your medical history with your doctor or pharmacist, particularly any of the following conditions: breathing issues (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea); blood and immune system problems (such as bone marrow depression); high pressure in the eye (glaucoma); heart disease (such as irregular heartbeat); high blood pressure; liver disease; certain brain disorders (such as neuroleptic malignant syndrome, Reye (for example, due to enlarged prostate).

This medication may cause you to feel drowsy, lightheaded, or distort your vision. Drinking alcohol or smoking marijuana (also known as cannabis) can make you feel more lightheaded and sleepy. Do not operate a motor vehicle, any machinery, or engage in any activity that requires alertness or clear vision until you are able to complete them safely. Steer clear of beverages containing alcohol. If you are a marijuana user, you should consult your primary care physician (cannabis).

Before undergoing surgery, it is important to discuss all of the products you use with your dentist or doctor (including prescription drugs, nonprescription drugs, and herbal products).

There is a possibility that using this medication will increase your photosensitivity. Reduce the amount of time you spend in the sun. Stay away from tanning beds and indoor sunlamps. When you go outside, make sure to put on sunscreen and protective gear. If you acquire a sunburn or see any blisters or redness on your skin, make an appointment with your primary care physician as soon as possible.

This prescription may cause you to sweat less, which increases the risk that you will suffer from heat stroke. Stay away from activities that could cause you to overheat, such as working hard or exercising outside while the temperature is high, or utilizing hot tubs. When the temperature is high, it is important to consume enough fluids and wear lightweight clothing. In the event that you become overheated, you should immediately look for a place where you can cool off and rest. You should seek immediate medical attention if you develop a fever that does not go away, changes in your mental state or mood, a headache, or dizziness.

Products that are liquid can have sugar and/or alcohol in them. If you have diabetes, liver illness, or any other condition that requires you to limit or avoid the consumption of these chemicals in your diet, you should exercise extreme caution. Talk to your primary care physician or your local pharmacist about the proper use of this medicine.

It is possible that children are more vulnerable to the adverse effects of this medication, particularly the slowing down of their breathing and the loss of control they have over their movements (see also Warning section). Young children are more likely to experience enthusiasm than sleepiness as a side effect of this medicine. When administering this drug to children, extra caution should be exercised in the case that the patient has experienced significant fluid loss (dehydration), the patient’s family has a history of sudden infant death syndrome (SIDS), or the patient has trouble waking up from sleep.

It’s possible that senior citizens are more sensitive to the negative effects of this medication, particularly drowsiness, disorientation, constipation, and urinary incontinence. There is a correlation between drowsiness and an increased risk of falling.

During pregnancy, it is important to only use this drug when it is absolutely necessary. Talk to your healthcare provider about the potential drawbacks and advantages.

It is not known whether or if promethazine is found in breast milk. A nursing infant is at risk of experiencing unfavorable outcomes as a result of this. Before starting to breastfeed, you should talk to your healthcare provider.

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Drug interactions can alter the way in which your prescriptions work or raise the likelihood that you will have major adverse effects. This document does not contain all possible medication interactions. Maintain a list of all the goods you use, including prescription and over-the-counter medications, as well as herbal remedies, and give it to both your primary care physician and your pharmacist. Without first consulting your physician, you should never alter the dosage of any medication, stop taking any medication, or start taking any new medication.

Antihistamines that are applied to the skin (such as diphenhydramine cream, ointment, or spray), as well as metoclopramide, are examples of products that have the potential to interact with this medication.

If this drug is taken with other products that may also cause drowsiness or breathing issues, the chance of serious side effects (such as slow or shallow breathing, and severe drowsiness/dizziness) may be increased. These adverse effects include slow or shallow breathing, and severe drowsiness/dizziness. Tell your doctor or pharmacist if you are taking any other medications, including opioid pain relievers or cough relievers (such as codeine or hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), or other antihistamines. These medications can interact with the effects of this medication (such as cetirizine, and diphenhydramine).

You should read the labels on all of your medications (such as those meant to treat allergies or coughs and colds) since some of them may contain substances that make you feel sleepy. Talk to your local pharmacist about the proper way to use those products.

This medicine has the potential to interfere with a variety of laboratory tests, including those used to detect pregnancy, glucose tolerance, and skin-prick allergy testing, potentially leading to inaccurate test findings. Ensure that the employees in the laboratory and all of your doctors are aware that you are using this medication.


Dial 911 if you suspect that someone has overdosed and they are exhibiting serious symptoms such as passing out or having problems breathing. In any other case, you should immediately contact a poison control center. To reach the poison control center for your area in the United States, dial 1-800-222-1222. Canadian residents can call a provincial poison control center. Extreme drowsiness or dizziness may be one of the symptoms of an overdose, along with passing out, shallow or shallow breathing, fainting, convulsions, muscle stiffness or twitching, and dilated pupils. Before drowsiness sets in, children may experience mental and emotional shifts, such as anger, restlessness, and hallucinations.


This drug should not be given to anyone else.

Neglected Dose

If you forget to take a dose, you should take it as soon as you realize you forgot. If it is getting close to the time of the next dose, you should forgo the dose that you missed. Your next dose should be taken at the typical time. It is not necessary to double the dose in order to catch up.


Keep at room temperature and away from light and moisture. Store at room temperature. Keep away from the bathroom at all costs. Always make sure that children and animals are kept well away from any medications.

Unless you have been specifically told to do so, you should not flush drugs down the toilet or pour them down a drain. When it is no longer needed or has passed its expiration date, dispose of this product in the appropriate manner. Talk to your neighborhood pharmacy or the firm that handles garbage disposal in your area.

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