Isosorbide Mononitrate - Uses, Side Effects, Warnings, and More

Isosorbide Mononitrate – Uses, Side Effects, Warnings, and More

Isosorbide Mononitrate – Uses, Side Effects, Warnings, and More

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Isosorbide mononitrate is prescribed to people who suffer from a specific type of cardiac problem in order to alleviate chest pain also known as angina (coronary artery disease). This substance is a member of the nitrate family, which is a group of medications with similar effects. It does this by relaxing the blood arteries and making them wider, which makes it easier for blood to flow to the heart.

Once the chest discomfort has started, this drug will not help relieve it. In addition, it is not recommended to take it right before engaging in any kind of physical activity, including exercise or sexual activity, in order to prevent chest pain. Your doctor may also prescribe you other medications in order to treat these issues. Consult your doctor for additional details.

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How to use Isosorbide Mononitrate

You should take this medication by mouth exactly as instructed by your physician, which is often twice daily. The first dose of the day should be taken as soon as you get up, and the second dose should be taken seven hours later. It is essential that the medication be administered at the same time each day. If recommended by your doctor, you should not alter the times that you take your doses.

Make sure you take this medication as directed for it to have the desired effect. Take it at the same times every day so that you don’t forget. This will assist. Do not discontinue taking it without first discussing it with your healthcare provider. When the medication is suddenly discontinued, several conditions may become even more severe. It’s possible that your current dose needs to be gradually lowered.

If this drug is taken for an extended period of time, there is a possibility that it could lose some of its effectiveness and that the recommended dosage will need to be adjusted. Notify your physician if you notice that this drug is no longer working well (for example, you have more frequent or worsening chest pain).

Side Effects

As your body responds to this drug, you may have side effects such as headache, dizziness, lightheadedness, nausea, and flushing. Notify your doctor or pharmacist as soon as possible if any of these side effects continue or become worse.

A headache is frequently experienced when the drug is beginning to take effect. It’s possible that your physician will advise you to manage headaches using over-the-counter pain medication (such as acetaminophen, or aspirin). In the event that your headaches persist or worsen, you should consult your physician as soon as possible.

When rising from a seated or laying position, it is important to do so carefully in order to limit the likelihood of experiencing dizziness and lightheadedness.

Keep in mind that the reason your doctor has recommended that you take this medication is that he or she believes that the potential benefits to you outweigh the potential risks of doing so. The majority of persons who take this medicine do not report experiencing any severe adverse effects.

Notify your healthcare provider as soon as possible if you experience any major adverse effects, such as feeling dizzy or having a heartbeat that is abnormally fast, irregular, or hammering.

It is quite unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you detect any symptoms of a significant allergic reaction, such as a rash, itching/swelling (particularly of the face/tongue/throat), extreme dizziness, or difficulty breathing. These symptoms may indicate anaphylaxis.

This list of potential adverse effects is not exhaustive in any way. Please consult your physician or pharmacist if you have any side effects that are not listed above.

In the United States, if you are experiencing any adverse effects, please consult your primary care physician. You can call the FDA at 1-800-FDA-1088 or visit their website at to report any adverse effects.

In Canada, if you are experiencing any adverse effects, please consult your primary care physician. You can call Health Canada at 1-866-234-2345 to report any adverse effects you experience.

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Before you use this medication, tell your doctor or pharmacist if you have any allergies, including those to the medication itself, to other drugs that work in a similar way (such as isosorbide dinitrate or nitroglycerin), or to any other substances. There is a possibility that this product contains inactive substances, which, if present, could result in allergic responses or other complications. Discuss the matter further with your pharmacist for further information.

Before beginning treatment with this drug, it is important that you discuss your medical history, in particular any episodes of low blood pressure.

This medication could cause you to feel lightheaded. Alcohol or marijuana (cannabis) can make you more dizzy. Do not get behind the wheel of a vehicle, operate any machinery, or engage in any activity that requires attentiveness until you are able to do it safely. Reduce your intake of alcoholic beverages. Talk to your doctor if you are smoking marijuana (cannabis).

Before undergoing surgery, it is important to discuss all of the products you use with your dentist or doctor (including prescription drugs, nonprescription drugs, and herbal products).

It’s possible that older people are more sensitive to the negative effects of this medication, particularly the dizziness and lightheadedness that might come with it, which can raise the risk of falling.

During pregnancy, this drug should only be taken when it is absolutely necessary to do so. Talk to your healthcare provider about the potential drawbacks and advantages.

It is not known if this medicine is detected in breast milk if it is taken. Before starting to breastfeed, you should talk to your healthcare provider.


Drug interactions can alter the way in which your prescriptions work or raise the likelihood that you will have major adverse effects. This document does not contain all possible medication interactions. Maintain a list of all the goods you use, including prescription and over-the-counter medications, as well as herbal remedies, and give it to both your primary care physician and your pharmacist. Without first seeing your physician, do not start, stop, or alter the dosage of any medications you are now taking.

Drugs used to treat erectile dysfunction (ED) or pulmonary hypertension (such as sildenafil or tadalafil), as well as riociguat, are examples of goods that have the potential to interact negatively with this medication.

There are some items on the market that include components that could make your heart failure worse. Tell your pharmacist what products you are using and ask for instructions on how to use them safely. This is especially important for over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen.

Isosorbide mononitrate is extremely similar to isosorbide dinitrate. While you are taking isosorbide mononitrate, you should avoid taking any medications that include isosorbide dinitrate.

This medicine has the potential to skew the findings of certain laboratory tests, especially those measuring cholesterol levels, perhaps leading to an inaccurate diagnosis. Ensure that the employees in the laboratory and all of your doctors are aware that you are using this medication.


Dial 911 if you suspect that someone has overdosed and they are exhibiting serious symptoms such as passing out or having problems breathing. In any other case, you should immediately contact a poison control centre. To reach the poison control centre for your area in the United States, dial 1-800-222-1222. Canadian residents can call a provincial poison control centre. Overdose can cause a variety of symptoms, including a slow heartbeat, changes in eyesight, severe nausea and vomiting, profuse perspiration, cold and clammy skin, and bluish fingers, toes, and lips.


This drug should not be given to anyone else.

Tests in the laboratory and/or examinations by a doctor (such as monitoring your blood pressure) should be carried out on a regular basis in order to track your improvement and identify any potential adverse reactions. Consult your doctor for additional details.

Alterations to one’s way of life, such as one’s diet, physical activity level, and smoking status, may help this medication operate more effectively. Talk to your primary care physician or your pharmacist about making adjustments to your lifestyle that could be beneficial to you.

Neglected Dose

If you forget to take a dose, you should take it as soon as you realise you forgot. If there will be less than two hours before the next scheduled dose, you should forgo the dose you missed. Your next dose should be taken at the typical time. It is not necessary to double the dose in order to catch up.


Keep at room temperature and away from light and moisture. Store at room temperature. Keep away from the bathroom at all costs. Always make sure that children and animals are kept well away from any medications.

Unless you have been specifically told to do so, you should not flush drugs down the toilet or pour them down a drain. When it is no longer needed or has passed its expiration date, dispose of this product in the appropriate manner. Talk to your neighbourhood pharmacy or the firm that handles garbage disposal in your area.

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