Ginkgo – Uses, Side Effects, Warnings, And More

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Overview

Ginkgo (Ginkgo biloba) is the scientific name for a big tree that has leaves shaped like fans. Memory issues are a popular reason for people to consume the leaves in the form of dietary supplements or by mouth.

It is believed that the ginkgo tree is one of the oldest living trees, with a history that stretches back more than 200 million years. Although it was originally cultivated in China, Japan, and Korea, it is now extensively cultivated in Europe and the United States. It seems to increase blood circulation and may also function as an antioxidant to slow down changes in the brain. Both of these effects would be beneficial.

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Ginkgo has been around for such a significant amount of time that people have found numerous uses for it. It is often taken orally for issues related to memory and thought, anxiety, eye impairments, and a wide variety of other diseases; however, there is insufficient reliable scientific data to support the majority of these uses.

What Are the Benefits and Applications?

Potentially Helpful in Treating Anxiety If you take an extract of ginkgo called EGb 761 manufactured by Dr. Willmar Schwabe Pharmaceuticals and take it orally for a period of four weeks, you may notice a little decrease in the symptoms of anxiety.

Cognitively impairing diseases such as Alzheimer’s disease and other such conditions (dementia). There is some evidence that taking 240 milligrammes of ginkgo biloba orally every day can help improve dementia symptoms. It appears that ginkgo does not prevent dementia from occurring or make the condition better.

Hearing impairment Together with regular treatment, administering ginkgo by intravenous infusion to patients who have suddenly lost their hearing can help improve hearing. It is unclear whether or not ingesting ginkgo is beneficial. Only a trained medical professional should administer IV medications.

Premenstrual syndrome (PMS). It appears that taking an extract of ginkgo leaf by mouth will alleviate breast pain as well as other symptoms linked with premenstrual syndrome. To apply it in this manner, one begins doing so on the 16th day of the menstrual cycle and keeps doing so until the 5th day of the cycle that follows.

Schizophrenia. Some symptoms of schizophrenia can be alleviated by supplementing standard antipsychotic treatment with the oral consumption of ginkgo leaf extract on a daily basis for a period of eight to sixteen weeks. It is also possible that it will minimise the negative effects of antipsychotic medications, such as dry mouth, constipation, and tardive dyskinesia, which is a movement problem.

Stroke. People who are recuperating from a stroke appear to experience improvements in their thinking, memory, and capacity to carry out activities of daily living when they combine normal therapy with the administration of ginkgo extract either orally or intravenously. It’s possible that taking ginkgo extract orally won’t be as beneficial as administering it intravenously. However, an IV product can only be administered by a trained medical professional.

Dizziness (vertigo). It would appear that the symptoms of dizziness brought on by balance issues can be alleviated by ingesting ginkgo leaf extract. It is not quite known whether or not this helps to ameliorate vertigo symptoms in persons who have a condition that causes the reduced blood supply to the brain.

It’s Possible That This Won’t Work for

Memory loss and a general slowing of thought processes are both natural consequences of advancing age. It has not been shown that orally ingesting ginkgo can boost the memory or thinking abilities of elderly persons.

Antidepressants have been linked to sexual dysfunction (antidepressant-induced sexual dysfunction). There is no correlation between oral consumption of ginkgo leaf extract and an improvement in sexual dysfunction brought on by the use of antidepressants.

Coronary artery disease Consuming ginkgo through the digestive system does not lower the risk of having a heart attack, chest discomfort, or stroke in adults over the age of 65.

Memory loss and other cognitive problems have been observed in cancer patients receiving chemotherapy. People undergoing treatment for breast cancer who take ginkgo in pill form won’t experience any protection against the cognitive side effects of chemotherapy.

Elevated levels of blood pressure. People over the age of 60 who have high blood pressure and take ginkgo leaf extract orally for up to six years do not experience a reduction in their blood pressure.

Multiple sclerosis (MS). Multiple sclerosis patients who take ginkgo leaf extract or ginkgolide B, a specific molecule that can be found in ginkgo extract, will not experience an improvement in their mental function or impairment as a result of doing so.

Tones audible in the ears (tinnitus). It does not appear that taking an extract of ginkgo leaf by mouth will help improve ringing in the ears.

There is an interest in utilising ginkgo for a variety of additional uses; however, there is insufficient trustworthy information to determine whether or not this could be beneficial.

Adverse Reactions

When consumed via the oral route: It is very likely that Ginkgo LEAF EXTRACT is safe for the vast majority of people. It is possible for it to cause some minor adverse effects, such as gastrointestinal distress, headache, lightheadedness, and skin allergic responses. There is some evidence to suggest that taking ginkgo leaf extract may raise the risk of bruising and bleeding, as well as the risk of developing an irregular heartbeat.

When consumed orally, the ROASTED SEED and CRUDE GINKGO PLANT could potentially cause adverse effects. Consuming more than ten roasted seeds on a daily basis has the potential to lead to major adverse effects such as convulsions. Consuming FRESH SEEDS poses a potential risk of death. They are dangerous due to the fact that they are poisonous.

There is not enough trustworthy information available to determine whether or not ginkgo is safe to use on the skin.

Important Safety Instructions and Cautionary Notes

Ginkgo may pose a risk to the health of the unborn child if it is consumed by mouth during pregnancy. If taken close to the time of delivery, it could trigger early labour and increase the amount of bleeding that occurs during the process.

When it comes to breastfeeding, there just isn’t enough trustworthy information to determine whether or not ginkgo is safe to consume. To be on the safe side, you should avoid using it.

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When administered orally to children for a limited period of time, ginkgo leaf extract may not cause any adverse effects. When used in small doses and for a short period of time, a specific combination of ginkgo leaf extract and American ginseng may be safe for use in children. Children should not be allowed to eat the ginkgo seed. Children have experienced seizures and sometimes died as a result of the raw seeds.

Bleeding problems: Ginkgo might make bleeding disorders worse. Ginkgo should not be used by anyone who has a bleeding condition.

Cross-reactivity: Individuals who are allergic to poison ivy, poison oak, poison sumac, mango rind, or cashew shell oil may also be allergic to ginkgo. Other possible allergens include ginkgo biloba and cashew shell oil.

Ginkgo may cause complications for those who are trying to control their diabetes. If you have diabetes, you need to keep a constant eye on your blood sugar.

Seizures: Ginkgo might cause seizures. Ginkgo should not be used by anyone who has ever experienced a seizure.

G6PD stands for glucose-6-phosphate dehydrogenase. Ginkgo may induce severe anaemia in those who are deficient in the G6PD enzyme. If you have a G6PD deficiency, use ginkgo with extreme caution or completely avoid it until more is learned about it.

Ginkgo use may reduce a woman’s chances of conceiving a healthy child. If you are trying to conceive a child, you should talk to your healthcare professional about using ginkgo while you are doing so.

Ginkgo may make it less likely for blood to clot during surgery. It could result in increased bleeding both during and after the operation. Put an end to your use of ginkgo at least two weeks before your scheduled surgical procedure.

What are the interactions?

Significant Participation

Do not combine these medications in any way.

Sustiva’s efavirenz (also known as Efavirenz) interacts with GINKGO.

Efavirenz is a drug that is used in the treatment of HIV infection. It is possible that the effects of efavirenz will be lessened if you take ginkgo extract at the same time. If you are currently using efavirenz, you should see your healthcare provider before beginning treatment with ginkgo.

There is an interaction between talinolol and GINKGO.

It’s possible that taking ginkgo leaf extract numerous times a day will cause an increase in talinolol levels. It’s possible that this will make the talinolol’s effects and adverse effects worse. It appears that the levels of talinolol are unaffected by the consumption of a single dose of ginkgo.

Interaction that is Not Overbearing

Take precautions when using these two together.

There is a drug interaction between alprazolam (Xanax) and GINKGO.

It is possible that the effects of alprazolam will be lessened in some individuals if they take ginkgo in conjunction with their medication.

Ibuprofen (Advil, Motrin, and others) and GINKGO have a drug interaction.

It’s possible that ginkgo can prevent blood from clotting. Ibuprofen has been shown to inhibit the coagulation of blood. Taking ginkgo along with ibuprofen may cause an excessive slowing of blood coagulation, which can lead to an increased risk of bleeding and bruising. If you are already using ibuprofen, you should see your healthcare professional before beginning to use ginkgo.

Medications that are metabolised by the liver, known as substrates for cytochrome P450 1A2 (CYP1A2), interact with GINKGO.

The liver is responsible for the transformation and breakdown of certain drugs. It’s possible that ginkgo will alter the rate at which the liver processes these drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

Medications that are metabolised by the liver, often known as substrates for the cytochrome P450 2C19 enzyme, interact with GINKGO.

The liver is responsible for the transformation and breakdown of certain drugs. It’s possible that ginkgo will alter the rate at which the liver processes these drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

Medications that are metabolised by the liver, often known as substrates for the cytochrome P450 2C9 enzyme, interact with GINKGO.

The liver is responsible for the transformation and breakdown of certain drugs. It’s possible that ginkgo will alter the rate at which the liver processes these drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

GINKGO interacts with medications that are metabolised by the liver, also known as substrates of the cytochrome P450 3A4 enzyme.

The liver is responsible for the transformation and breakdown of certain drugs. It’s possible that ginkgo will alter the rate at which the liver processes these drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

Diabetes medications, often known as anti-diabetes treatments, can interfere with the effects of GINKGO.

There is a possibility that ginkgo will raise blood sugar levels. It is possible that taking ginkgo in conjunction with diabetic medicine will lessen the effectiveness of the diabetes treatment. Keep a tight eye on your blood sugar levels.

GINKGO has the potential to interact with pharmaceuticals that reduce the seizure threshold, which are medications that raise the risk of having a seizure.

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It’s possible that ginkgo could make certain people more prone to having seizures. In addition, there are some pharmaceuticals that have been shown to raise the probability of having a seizure. Taking both of these products at the same time may enhance the likelihood of having a seizure even further.

GINKGO has a negative interaction with medications that slow blood clotting, known as anticoagulants and antiplatelet medicines.

It’s possible that ginkgo can prevent blood from clotting. When combined with drugs that similarly reduce blood clotting, the use of ginkgo may increase the likelihood of experiencing bleeding and bruises.

Anticonvulsants, which are medications intended to prevent seizures, have been shown to interact with GINKGO.

It’s possible that ginkgo could make seizures worse. Consequently, consuming ginkgo may lessen the effectiveness of the medicines that are normally taken to avoid seizures. This might make the chance of having seizures higher.

Desyrel (trazodone) has a drug interaction with GINKGO.

There is a possibility that ginkgo will amplify the effects of trazodone. When used together, ginkgo and trazodone have the potential to trigger major adverse reactions in the brain.

The blood thinner Warfarin (Coumadin) reacts with GINKGO.

Warfarin is taken to reduce the likelihood of blood clots forming. Ginkgo may also lessen the likelihood of blood clots forming. If you take warfarin and ginkgo at the same time, your risk of bruising and major bleeding may increase. Always remember to get your blood examined on a regular basis. It’s possible that your current dose of warfarin needs to be adjusted.

There is a drug interaction between atorvastatin (Lipitor) and GINKGO.

There is a possibility that ginkgo will hasten the rate at which the body eliminates atorvastatin. It is not entirely obvious whether this is a major cause for concern. It does not appear that the use of ginkgo will mitigate the effects of atorvastatin on cholesterol levels.

Risperidone (Risperdal) combines with GINKGO to produce an interaction.

There is a possibility that ginkgo will slow down the rate at which risperidone is metabolised by the liver. Risperidone’s adverse effects, such as sleepiness, dizziness, and dry mouth, could become more likely as a result of this interaction.

Simvastatin (Zocor) interacts with GINKGO

Ginkgo might boost how quickly the body gets rid of simvastatin. It is not entirely obvious whether this is a major cause for concern. It does not appear that ginkgo has any effect on the reduction of cholesterol levels brought about by simvastatin.

P-Glycoprotein Substrates, which are medications that are transported around in cells by pumps, interact with GINKGO.

Pumps are responsible for transporting some drugs into and out of cells. Ginkgo could alter the functioning of these pumps, so affecting the amount of medication that is retained in the body. This could potentially alter the effects of a medication, as well as its potential adverse effects.

A Slightly Interacting Party

Take caution when using these two together.

Omeprazole, often known as Prilosec, has a drug interaction with GINKGO.

There is a possibility that ginkgo will hasten the rate at which the liver breaks down omeprazole. It’s possible that taking ginkgo while also taking omeprazole will make the medication less effective.

There is a drug interaction between nifedipine (Procardia) and GINKGO.

It is possible that the levels of nifedipine in the body will rise if you consume both ginkgo and nifedipine orally. There is a possibility that this will make the adverse effects of nifedipine, such as headaches, dizziness, and hot flashes, worse.

Dosing

Adults have been known to take doses of ginkgo ranging from 60 to 240 milligrammes (mg) orally, once daily, for up to six months. It is possible that the dosage will change depending on the particular formulation that is utilised. Products that have undergone the greatest research are often those that have been standardised to include extracts of ginkgo leaf. Talk to a medical professional about your symptoms to get a recommendation on the appropriate dosage for your condition.

Keep in mind that there are frequently problems with the quality of ginkgo products. In place of ginkgo, some producers of lower quality may utilise alternative, more cost-effective components such as rutin and quercetin. Both of these compounds are found naturally in ginkgo, and because of this, the addition of these chemicals to ginkgo products can make those goods appear to be ginkgo in certain tests. However, the effects of these products would not be the same as those of ginkgo.