Rexulti - Uses, Side Effects, Warnings, and More

Rexulti – Uses, Side Effects, Warnings, and More

Rexulti – Uses, Side Effects, Warnings, and More

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How to use Rexulti

Before beginning to use brexpiprazole and whenever you get a refill for your prescription, make sure you have read the Patient’s Medication Guide provided by your pharmacist. If you have any questions, you should consult with either your physician or your pharmacist.

Take this drug exactly as advised by your physician, either with or without meals and in most cases only once per day. Your current medical condition, how well you are responding to treatment, and any other medications you may be taking all play a role in determining the appropriate dosage for you. Make sure to inform both your primary care physician and your pharmacist about all of the products you use (including prescription drugs, nonprescription drugs, and herbal products).

It is possible that your physician will instruct you to begin treatment with this medicine at a low dose and then gradually increase that dose over the course of a few days. Be sure to pay close attention to the directions that your doctor gives you.

It is important to maintain consistent use of this drug in order to get the most out of it. Take it at the same time every day so that you don’t forget when you’re supposed to.

Even if you are feeling better and thinking more clearly, you should keep taking this medication exactly as directed even if the dosage has been adjusted. Do not take this medication in larger amounts or more frequently than directed by your doctor. Your symptoms will not improve any more quickly, and you will be at an increased risk of experiencing adverse consequences. It is important that you speak with your healthcare provider before discontinuing the use of this medicine.

If your symptoms do not improve or if they become worse, you should consult your physician. It is possible that it will be several weeks before you experience the full benefit of this drug.

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Adverse Reactions

Please also see the section labeled Warning.

There is a possibility that taking this medication will cause drowsiness, dizziness, lightheadedness, shaking, increased hunger, weight gain, restlessness, and difficulty sitting still. Notify your doctor or pharmacist as soon as possible if any of these side effects continue or become worse.

It is possible for this medicine to induce a significant reduction in blood pressure, particularly when the medication is first started or when the dosage is increased. The symptoms of vertigo, including dizziness and lightheadedness, can make falling more likely. When rising from a seated or lying posture, do it in a gradual and steady manner.

Keep in mind that the reason your doctor has recommended that you take this medication is that he or she believes that the potential benefits to you outweigh the potential risks of doing so. The majority of persons who take this medicine do not report experiencing any severe adverse effects.

Notify your physician as soon as possible if you have any serious side effects, including but not limited to: problems swallowing, fainting, disturbed breathing while sleeping, and unusually intense cravings (such as increased gambling, and increased sexual urges).

Tardive dyskinesia is a disorder that could be caused by using brexpiprazole in extremely rare cases. This condition may be permanent in some people, but not always. Notify your primary care provider immediately if you notice any movements that are abnormal or out of control (especially of the face, lips, mouth, tongue, arms, or legs).

It is possible that this drug will induce a slight elevation in your blood sugar, which can either bring on diabetes or make the condition worse. If you have symptoms of high blood sugar such as excessive thirst or urine, you should contact your doctor as soon as possible. If you have diabetes already, you should have your blood sugar checked on a regular basis as instructed by your doctor and discuss the results with him or her. It’s possible that your diabetic medication, exercise routine, or diet will need some tweaking from your doctor.

This medication might also cause you to put on weight and have an increase in the amount of cholesterol (or triglycerides) in your blood. These consequences, in conjunction with diabetes, may raise your likelihood of getting cardiovascular disease. Talk to your doctor about the potential drawbacks and advantages of the treatment.

This drug has a remote possibility of elevating the level of a particular hormone already present in your blood (prolactin). If a woman’s prolactin levels rise, she may produce breast milk that is not wanted, experience irregular or absent menstruation, or have trouble getting pregnant. It is possible for men to have a reduction in their sexual ability, an inability to generate sperm or an enlargement of the breasts. Inform your healthcare provider as soon as possible if you have any of these symptoms.

In the event that you experience any very significant adverse effects, including seizures, seek immediate medical attention.

This medicine carries a very low risk of causing the neuroleptic malignant syndrome, but there is a chance that it could (NMS). If you develop any of the following symptoms, you should seek immediate medical attention: fever, muscle stiffness/pain/tenderness/weakness, extreme weariness, extreme disorientation, sweating, fast/irregular heartbeat, dark urine, evidence of kidney difficulties (such as a change in the amount of urine).

It is quite unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you detect any symptoms of a significant allergic reaction, such as a rash, itching/swelling (particularly of the face/tongue/throat), extreme dizziness, or difficulty breathing. These symptoms may indicate anaphylaxis.

This list of potential adverse effects is not exhaustive in any way. Please consult your physician or pharmacist if you have any side effects that are not listed above.

In the United States, if you are experiencing any adverse effects, please consult your primary care physician. You can call the FDA at 1-800-FDA-1088 or visit their website at to report any adverse effects.

In Canada, if you are experiencing any adverse effects, please consult your primary care physician. You can call Health Canada at 1-866-234-2345 to report any adverse effects you experience.

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Please also see the section labeled Warning.

Inform your doctor or pharmacist if you are allergic to brexpiprazole, as well as if you have any additional allergies, before beginning treatment with the medication. There is a possibility that this product contains inactive substances, which, if present, could result in allergic responses or other complications. Discuss the matter further with your pharmacist for further information.

Before beginning treatment with this medication, it is important that you discuss your medical history with your doctor or pharmacist, particularly if you have a history of dementia, kidney problems, liver problems, personal or family history of diabetes, high cholesterol/triglyceride levels, heart problems, seizures, stroke, difficulty swallowing, a low white blood cell count, or breathing problems while sleeping (sleep apnea).

This medication could cause you to feel lightheaded or sleepy. Drinking alcohol or smoking marijuana (also known as cannabis) can make you feel more lightheaded and sleepy. Do not get behind the wheel of a vehicle, operate any machinery, or engage in any activity that requires attentiveness until you are able to do it safely. Steer clear of beverages containing alcohol. If you are a marijuana user, you should consult your primary care physician (cannabis).

Before undergoing surgery, it is important to discuss all of the products you use with your dentist or doctor (including prescription drugs, nonprescription drugs, and herbal products).

This prescription may cause you to sweat less, which increases the risk that you will suffer from heat stroke. Stay away from activities that could cause you to overheat, such as working hard or exercising outside while the temperature is high, or utilizing hot tubs. When the temperature is high, it is important to consume enough fluids and wear lightweight clothing. In the event that you become overheated, you should immediately look for a place where you can cool off and rest. You should seek immediate medical attention if you develop a fever that does not go away, changes in your mental state or mood, a headache, or dizziness.

It’s possible that senior citizens are more vulnerable to the negative effects of this medication, particularly the sleepiness, dizziness, and lightheadedness it can cause. There is a correlation between drowsiness and an increased risk of falling, as are dizziness and lightheadedness

During pregnancy, it is important to only use this drug when it is absolutely necessary. Babies who are born to mothers who have used this medication during the final three months of pregnancy have a very small chance of developing symptoms such as muscle stiffness or shakiness, drowsiness, difficulty feeding or breathing, or continual crying. These symptoms can occur in very rare cases. Immediately consult a medical professional if you observe any of these signs in your infant, particularly within the first month of their life.

Do not stop taking this medication unless specifically ordered to do so by your doctor. Untreated mental and mood disorders (such as schizophrenia and depression) can be serious conditions if left untreated. Discuss the potential benefits and dangers of using this drug while pregnant with your attending physician as soon as possible if you are contemplating becoming pregnant, if you already are pregnant, or if you suspect that you may be pregnant.

There is no evidence to suggest that this medicine makes its way into breast milk. Before starting to breastfeed, you should talk to your healthcare provider.

Please seek the advice of your pharmacist or physician.

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Drug interactions can alter the way in which your prescriptions work or raise the likelihood that you will have major adverse effects. This document does not contain all possible medication interactions. Maintain a list of all the goods you use, including prescription and over-the-counter medications, as well as herbal remedies, and give it to both your primary care physician and your pharmacist. Without first consulting your physician, you should never alter the dosage of any medication, stop taking any medication, or start taking any new medication.

Metoclopramide is a medicine that could potentially interact with this medication.

Tell your doctor or pharmacist if you are taking any other products that cause drowsiness, including opioid pain relievers or cough relievers (such as codeine or hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

You should read the labels on all of your medications (such as those meant to treat allergies or coughs and colds) since some of them may contain substances that make you feel sleepy. Talk to your local pharmacist about the proper way to use those products.


Dial 911 if you suspect that someone has overdosed and they are exhibiting serious symptoms such as passing out or having problems breathing. In any other case, you should immediately contact a poison control center. To reach the poison control center for your area in the United States, dial 1-800-222-1222. Canadian residents can call a provincial poison control center.


This drug should not be given to anyone else.

While you are taking this medicine, you may be subjected to clinical laboratory and/or medical testing (such as checks on your blood sugar, blood pressure, kidney and liver function, weight, and cholesterol and triglyceride levels). Make sure you don’t miss any of your doctor or lab appointments.

Neglected Dose

If you forget to take a dose, you should take it as soon as you realize you forgot. If it is getting close to the time of the next dose, you should forgo the dose that you missed. Your next dose should be taken at the typical time. It is not necessary to double the dose in order to catch up.


Keep at room temperature and away from light and moisture. Store at room temperature. Keep away from the bathroom at all costs. Always make sure that children and animals are kept well away from any medications.

Unless you have been specifically told to do so, you should not flush drugs down the toilet or pour them down a drain. When it is no longer needed or has passed its expiration date, dispose of this product in the appropriate manner. Talk to your neighborhood pharmacy or the firm that handles garbage disposal in your area.

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