Midodrine HCL - Uses, Side Effects, Warnings, and More

Midodrine HCL – Uses, Side Effects, Warnings, and More

Midodrine HCL – Uses, Side Effects, Warnings, and More

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Certain patients who exhibit signs of low blood pressure when standing are candidates for treatment with this drug. The term “orthosstatic hypotension” can also be used to refer to this disorder. People whose day-to-day activities are seriously impacted by this illness, even after they have tried other treatments, are candidates for the usage of midodrine (such as support stockings). It is a type of drug called a sympathomimetic, which operates on the blood vessels to raise blood pressure. Alpha receptor agonists are responsible for its effects.

How to make use of midodrine hydrochloride

You should take this medication by mouth as advised by your physician, usually three times a day. You can take it with or without food (at least 3 to 4 hours between doses). Be sure to pay close attention to each and every one of your doctor’s directions. The medicine is typically consumed during the afternoon, when people are more likely to be standing. It is not recommended to take this medication after the evening meal or any earlier than four hours before going to bed. It is not advisable to take your medication if you intend to spend a significant amount of time lying down afterward (for example, if you plan on taking a nap).

Your current health status and how you respond to treatment will determine the appropriate dosage for you. In order to lessen the likelihood of unpleasant side effects, your physician will likely start you on a low dose and gradually raise it over time. You should not raise your dose, nor should you take it more frequently than recommended by your doctor.

Make sure you take this medication as directed for it to have the desired effect. Take it at the same time every day so that you don’t forget. This will assist.

If your situation does not improve or if it gets worse, you should consult your doctor. Only those patients whose symptoms have improved while they are taking this medication should continue to take it.

Side Effects

Skin tingling, chills, “goose bumps,” stomach pain, or urine issues (such as a strong or frequent urge to urinate, frequent urination, or trouble urinating) are all possible side effects of using this medication. Dry mouth, dizziness, tiredness, difficulty sleeping, or leg cramps are some of the less common adverse effects that may occur. Notify your doctor or pharmacist as soon as possible if any of these side effects continue or become worse.

Keep in mind that the reason your doctor has recommended that you take this medication is that he or she believes that the potential benefits to you outweigh the potential risks of doing so. The majority of persons who take this medicine do not report experiencing any severe adverse effects.

It is possible for this drug to cause an increase in your blood pressure, particularly when you are lying down (supine hypertension). If you suffer any of the following symptoms of supine hypertension, you should immediately stop taking midodrine and make an appointment with your physician: pounding heartbeat, pounding in the ears, headache, and blurred vision.

In the event that you have any serious adverse effects, including a sluggish heartbeat, a strange feeling in the chest, fainting, pressure or fullness in the head, disorientation, anxiety, weakness, or visual difficulties, you should contact your doctor as soon as possible.

It is unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you detect any symptoms of a significant allergic reaction, such as a rash, itching/swelling (particularly of the face/tongue/throat), extreme dizziness, or difficulty breathing. These symptoms may indicate anaphylaxis.

This list of potential adverse effects is not exhaustive in any way. Please consult your physician or pharmacist if you have any side effects that are not listed above.

In the United States, if you are experiencing any adverse effects, please consult your primary care physician. You can call the FDA at 1-800-FDA-1088 or visit their website at www.fda.gov/medwatch to report any adverse effects.

In Canada, if you are experiencing any adverse effects, please consult your primary care physician. You can call Health Canada at 1-866-234-2345 to report any adverse effects you experience.

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Inform your doctor or pharmacist that you are allergic to midodrine, as well as if you have any additional allergies, before beginning treatment with this medication. There is a possibility that this product contains inactive substances, which, if present, could result in allergic responses or other complications. Discuss the matter further with your pharmacist for further information.

Before beginning treatment with this medication, it is imperative that you discuss your complete medical history with your attending physician. This should include conditions such as high blood pressure, pheochromocytoma, hyperthyroidism, difficulty urinating (caused by urinary retention or an enlarged prostate), heart disease, liver disease, kidney disease, and diabetes.

When rising from a seated or laying position, do it slowly to lessen the likelihood of becoming dizzy.

It is possible that this medication will cause you to get drowsy, lightheaded, or blurry your vision. Drinking alcohol or smoking marijuana (also known as cannabis) can make you feel more lightheaded and sleepy. Do not operate a motor vehicle, any machinery, or engage in any activity that requires alertness or clear vision until you are able to complete them safely. Reduce your intake of alcoholic beverages. If you are a marijuana user, you should consult your primary care physician (cannabis).

Inform your surgeon or dentist that you will be taking this medicine before you have any kind of procedure done.

Taking this drug while pregnant is not suggested by the manufacturer. It could cause harm to an unborn child. If you become pregnant or have any reason to believe that you may be pregnant, you should contact your doctor as soon as possible. Consult your doctor for additional details.

There is no evidence to suggest that this medicine makes its way into breast milk. Before starting to breastfeed, you should talk to your healthcare provider.


Drug interactions can alter the way in which your prescriptions work or raise the likelihood that you will have major adverse effects. This document does not contain all possible medication interactions. Maintain a list of all the goods you use, including prescription and over-the-counter medications, as well as herbal remedies, and give it to both your primary care physician and your pharmacist. Without first consulting your physician, you should never alter the dosage of any medication, stop taking any medication, or start taking any new medication.

There are several products on the market that include components that can cause your blood pressure to rise. Tell your pharmacist what products you are using and ask for instructions on how to use them safely. This is especially important for over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen.


Dial 911 if you suspect that someone has overdosed and they are exhibiting serious symptoms such as passing out or having problems breathing. In any other case, you should immediately contact a poison control center. To reach the poison control centre for your area in the United States, dial 1-800-222-1222. Canada residents can call a provincial poison control center. “Goose bumps,” difficulty urinating, and a sense of coldness are some of the symptoms that may accompany an overdose.


This drug should not be given to anyone else.

Checking one’s blood pressure when lying down, sitting, and standing at regular intervals is recommended. Discuss the findings with your primary care provider. (Also see the section on adverse effects.)

If you have high blood pressure and have trouble sleeping, elevating the head of your bed may help lower your blood pressure.

Tests in the laboratory and/or examinations by a doctor (checking your kidney and liver functions, for example) should be carried out on a regular basis in order to track your improvement and identify any potential adverse reactions. Consult your doctor for additional details.

Neglected Dose

If you forget to take a dose, you should take it as soon as you realise you forgot. If it is getting close to the time of the next dose, you should forgo the dose that you missed. Your next dose should be taken at the typical time. It is not necessary to double the dose in order to catch up.


Keep at room temperature and away from light and moisture. Store at room temperature. Keep away from the bathroom at all costs. Always make sure that children and animals are kept well away from any medications.

Unless you have been specifically told to do so, you should not flush drugs down the toilet or pour them down a drain. When it is no longer needed or has passed its expiration date, dispose of this product in the appropriate manner. Talk to your neighbourhood pharmacy or the firm that handles garbage disposal in your area.

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