Cymbalta - Uses, Side Effects, Warnings, and More

Cymbalta – Uses, Side Effects, Warnings, and More

Cymbalta – Uses, Side Effects, Warnings, and More

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The mental health conditions of depression and anxiety can be helped by taking duloxetine. In addition, duloxetine is prescribed to patients who suffer from nerve pain (peripheral neuropathy) as a result of diabetes or persistent pain as a result of medical diseases such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). It’s possible that duloxetine will help you feel less anxious while also enhancing your mood, sleep, appetite, and overall energy level.

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Additionally, it can lessen the discomfort that is caused by a variety of medical disorders. As a serotonin-norepinephrine reuptake inhibitor, duloxetine is one of the more common types of antidepressants (SNRI). This medicine is effective because it helps the brain to reestablish a balance between the levels of two naturally occurring molecules called serotonin and norepinephrine.

Cymbalta: How to Take It

Before beginning treatment with duloxetine and whenever you get a refill, make sure you have read the information contained in the Medication Guide and, if it is available, the Patient Information Leaflet that your pharmacist has provided you with. If you have any questions, you should consult with either your physician or your pharmacist.

You should take this medication orally as advised by your physician, which is often once or twice daily, regardless of whether you take it with or without food. If you are experiencing nausea, taking this medication with food may be of assistance. Take the capsule as directed and completely. You shouldn’t chew the capsule, crush it, or combine its contents with food or fluids in any way. This can cause the medicine to be released all at once, which raises the likelihood of experiencing adverse effects.

Your age, current health status, and how you respond to treatment all factor into the recommended amount. It is possible that your physician will instruct you to begin treatment with this medicine at a low dose and then gradually increase that dose over the course of a few days. Be sure to pay close attention to the directions that your doctor gives you. It is important to maintain consistent use of this drug in order to get the most out of it. Take it at the same time(s) every day so that you won’t forget when to take it.

Continue taking this medication even if you don’t feel like you need it. It is important that you speak with your healthcare provider before discontinuing the use of this medicine. It is possible that certain conditions will become even more severe if you suddenly stop taking this medication. In addition, you may have symptoms such as lightheadedness, confusion, irritability, headache, fatigue, diarrhea, altered sleep patterns, and fleeting sensations that are analogous to electric shocks. It is possible that your dose will need to be adjusted gradually in order to lessen the severity of the side effects. Notify your doctor immediately of any symptoms that are new or that have worsened.

Notify your primary care physician if your issue persists or worsens.

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Side Effects

There is a possibility that you will have nausea, dry mouth, constipation, loss of appetite, weariness, drowsiness, or increased perspiration. Notify your doctor as soon as possible if any of these side effects continue or become worse.

It is possible to experience vertigo or lightheadedness with taking this medication, particularly first beginning treatment with the medication or increasing the dosage. When rising from a seated or lying position, take your time in getting up to lessen the likelihood of experiencing vertigo, lightheadedness, or falling.

Keep in mind that the reason your doctor has recommended that you take this medication is that he or she believes that the potential benefits to you outweigh the potential risks of doing so. The majority of persons who take this medicine do not report experiencing any severe adverse effects.

It is possible that this drug will cause an increase in your blood pressure. Regularly checking your blood pressure and reporting any excessive readings to your physician is important.

Notify your physician as soon as possible if you experience any of the following serious side effects: confusion, easy bruising or bleeding, decreased interest in sex, changes in sexual ability, muscle cramps or weakness, shaking (tremor), difficulty urinating, signs of liver problems (such as nausea that does not stop, stomach/abdominal pain, vomiting, yellowing eyes/skin, and dark urine).

If you have any very significant side effects, such as black or bloody stools, vomit that looks like coffee grounds, a seizure, eye pain/swelling/redness, enlarged pupils, or vision problems, seek immediate medical attention (such as seeing rainbows around lights at night, blurred vision).

This medicine has the potential to raise serotonin levels, as well as the risk of a potentially fatal disease known as serotonin syndrome or poisoning. The danger is increased if you are also taking other medications that boost serotonin levels; thus, you should inform your physician or pharmacist of all the medications you now take. You should seek immediate medical attention if you have any of the following symptoms: a rapid heartbeat, hallucinations, lack of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation, or restlessness.

It is quite unusual for this medicine to cause an extremely severe allergic reaction. However, you should seek immediate medical attention if you experience any of the following symptoms of a major allergic reaction: rash, itching/swelling (particularly of the face/tongue/throat), extreme dizziness, difficulty breathing, skin blisters, or mouth sores.

This list of potential adverse effects is not exhaustive in any way. Please consult your physician or pharmacist if you have any side effects that are not listed above.

In the United States, if you are experiencing any adverse effects, please consult your primary care physician. You can call the FDA at 1-800-FDA-1088 or visit their website at to report any adverse effects.

In Canada, if you are experiencing any adverse effects, please consult your primary care physician. You can call Health Canada at 1-866-234-2345 to report any adverse effects you experience.


Inform your physician or pharmacist if you are allergic to duloxetine, or if you have any additional allergies before beginning treatment with duloxetine. There is a possibility that this product contains inactive substances, which, if present, could result in allergic responses or other complications. Discuss the matter further with your pharmacist for further information.

Before beginning treatment with this medication, it is important to discuss your medical history with your doctor or pharmacist, particularly any of the following: a personal or family history of psychiatric disorders (such as bipolar or manic-depressive disorder); a personal or family history of suicide attempts; bleeding problems; a personal or family history of glaucoma (angle-closure type); high blood pressure; kidney disease; liver disease; seizure disorder; stomach problems (such as slow emptying of the stomach); use

This medication could cause you to feel lightheaded or sleepy. Drinking alcohol or smoking marijuana (also known as cannabis) can make you feel more lightheaded and sleepy. Do not get behind the wheel of a vehicle, operate any machinery, or engage in any activity that requires attentiveness until you are able to do it safely. Steer clear of beverages containing alcohol. If you are a marijuana user, you should consult your primary care physician (cannabis).

It is possible that duloxetine will impact your blood sugar if you have diabetes. Check your blood sugar on a regular basis as instructed by your doctor, and then discuss the results with them. It’s possible that your diabetic medication, exercise routine, or diet will need some tweaking from your doctor.

Before undergoing surgery, it is important to discuss all of the products you use with your dentist or doctor (including prescription drugs, nonprescription drugs, and herbal products).

The adverse effects of this medication, particularly bleeding, dizziness, lightheadedness, or loss of coordination, could be felt more acutely by people of advanced age. The risk of developing a type of salt imbalance known as hyponatremia is increased in older persons, particularly among those who take medications known as “water pills” (diuretics). The risk of falling is increased when an individual experiences symptoms such as dizziness, lightheadedness, or loss of coordination.

It’s possible that children are more vulnerable to the negative effects of this medication, particularly the loss of appetite and decreased weight. Keep an eye on the child’s weight and height if they are on this medication. Note: Also see the Caution.

During pregnancy, it is important to only use this drug when it is absolutely necessary. If the mother takes this drug in the final month of her pregnancy, there is a possibility that there will be an increased risk of bleeding during delivery. This medicine has the potential to cause harm to an unborn child as well. Rarely, infants who are born to mothers who have used this medicine during the last three months of their pregnancies may have withdrawal symptoms after birth. These symptoms may include problems with feeding or breathing, convulsions, muscle rigidity, or persistent wailing. Notify the pediatrician as soon as possible if you observe any of these symptoms in your newborn child.

Do not stop taking this medicine unless specifically ordered to do so by your doctor; untreated mental and mood disorders (such as depression and anxiety) can be dangerous conditions if left untreated. Discuss the advantages and risks of using this medicine during pregnancy with your healthcare provider as soon as possible if you are planning a pregnancy, if you get pregnant, or if you have any reason to believe that you may be pregnant.

This medicine is excreted into breast milk and may have unintended consequences for an infant who is being breastfed. Before starting to breastfeed, you should talk to your healthcare provider.

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Drug interactions can alter the way in which your prescriptions work or raise the likelihood that you will have major adverse effects. This document does not contain all possible medication interactions. Maintain a list of all the goods you use, including prescription and over-the-counter medications, as well as herbal remedies, and give it to both your primary care physician and your pharmacist. Without first consulting your physician, you should never alter the dosage of any medication, stop taking any medication, or start taking any new medication.

Other medications that have the potential to induce bleeding or bruising are examples of goods that might have an interaction with this medication (including antiplatelet drugs such as clopidogrel, NSAIDs such as ibuprofen, “blood thinners” such as warfarin).

The elimination of duloxetine from your body can be impacted by the concomitant use of other drugs, which in turn can have an effect on how well duloxetine works. Cimetidine, viloxazine, and several quinolone antibiotics (such as ciprofloxacin and enoxacin) are a few examples of drugs that fall into this category.


This medicine has the potential to slow down the elimination of other medications from your body, which may have an effect on how effectively other treatments operate. Antiarrhythmic medications (such as propafenone, flecainide, and quinidine), antipsychotics (such as thioridazine), and tricyclic antidepressants (such as desipramine and imipramine) are some examples of the drugs that have been affected.


Taking MAO inhibitors in conjunction with this medication may result in a severe drug interaction, which could even be fatal. During your course of treatment with this drug, you should refrain from using any MAO inhibitors, including isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. The vast majority of MAO inhibitors shouldn’t be used for at least two weeks before therapy with this medicine, and they shouldn’t be taken for at least five days after treatment. Inquire with your physician regarding the appropriate timing to begin or stop using this medicine.


If you are also taking other drugs that enhance serotonin, you put yourself at a greater risk of developing serotonin syndrome or serotonin poisoning. Street drugs like MDMA or “ecstasy,” the herb St. John’s wort, certain antidepressants (including SSRIs like fluoxetine/paroxetine and other SNRIs like desvenlafaxine/venlafaxine), tryptophan, and a number of other substances are among examples. When you first begin taking these medications or raise your dosage, you may be putting yourself at a greater risk of developing serotonin syndrome or serotonin poisoning.

If you are taking other products that cause drowsiness, such as alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, or opioid pain relievers, you should let your doctor or pharmacist know (such as codeine). You should read the labels on all of your medications (such as those meant to treat allergies or coughs and colds) since some of them may contain substances that make you feel sleepy. Talk to your local pharmacist about the proper way to use those products.

When used with this drug, the usage of aspirin is associated with an increased risk of bleeding. If, on the other hand, your doctor has instructed you to take low-dose aspirin for the prevention of heart attack or stroke (usually 81-162 milligrams per day), you should keep taking it unless your doctor instructs you otherwise. Low-dose aspirin is typically prescribed in the range of 81-162 milligrams per day.


Dial 911 if you suspect that someone has overdosed and they are exhibiting serious symptoms such as passing out or having problems breathing. In any other case, you should immediately contact a poison control center. To reach the poison control center for your area in the United States, dial 1-800-222-1222. Canadian residents can call a provincial poison control center. Extreme sleepiness and fainting are two of the possible symptoms of an overdose.


This drug should not be given to anyone else.

Always be on time for your scheduled checkups and appointments with the psychiatrist. Tests in the laboratory and/or examinations by a doctor (including blood pressure and liver function, for example) should be carried out on a regular basis in order to track your improvement and identify any potential adverse reactions. Consult your doctor for additional details.

Neglected Dose

If you forget to take a dose, you should take it as soon as you realize you forgot. If it is getting close to the time of the next dose, you should forgo the dose that you missed. Your next dose should be taken at the typical time. It is not necessary to double the dose in order to catch up.


Keep at room temperature and away from light and moisture. Store at room temperature. Keep away from the bathroom at all costs. Always make sure that children and animals are kept well away from any medications.

Unless you have been specifically told to do so, you should not flush drugs down the toilet or pour them down a drain. When it is no longer needed or has passed its expiration date, dispose of this product in the appropriate manner. Talk to your neighborhood pharmacy or the firm that handles garbage disposal in your area.

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