5-Hydroxytryptophan – Uses, Side Effects, Warnings, and More

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Overview

In the body, serotonin can be produced from the amino acid 5-hydroxytryptophan, also known as 5-HTP. It is frequently used as a treatment for depression. It has a lower level of evidence for both anxiety and sleeplessness.

L-tryptophan is the building block of proteins, while 5-HTP is a chemical byproduct of that process. The seeds of a plant native to Africa known as Griffonia simplicifolia are used in the industrial production of this substance. 5-HTP stimulates an increase in the amount of the chemical serotonin that is produced in the brain and throughout the central nervous system. A person’s ability to sleep, appetite, temperature, sexual behavior, and sensations of discomfort can all be influenced by serotonin.

5-HTP is utilized in the treatment of illnesses in which serotonin is thought to play a key role because of its ability to raise serotonin levels. These illnesses include depression and anxiety, as well as a great many others; nevertheless, there is insufficient reliable scientific data to support the majority of these uses.

Uses & Effectiveness

Possible Usefulness in Regards to

Depression. Oral administration of 5-HTP appears to alleviate the depressive symptoms experienced by certain people. It is possible that it will work as effectively as certain antidepressant medications that require a prescription.

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It’s Possible That This Won’t Work for

Down syndrome. The vast majority of studies have shown that giving children with Down syndrome oral doses of 5-HTP does not help either their muscle strength or their overall development.

There is interest in utilizing 5-HTP for a number of additional uses; however, there is not enough information that can be relied upon to determine whether or not it might be helpful.

Side Effects

It is possible that taking 5-HTP at dosages of up to 400 mg per day for up to a year through oral consumption will not cause any adverse effects. Heartburn, stomach pain, nausea, vomiting, diarrhea, sleepiness, sexual dysfunction, and muscle dysfunction are the most typical adverse reactions that might occur when taking this medication. It is possible that taking large dosages of 5-HTP, such as 6-10 grams on a daily basis, could be harmful. There has been a connection made between these doses and serious issues with the stomach as well as muscle spasms.

There is evidence that 5-HTP use may be linked to the development of a potentially fatal illness known as eosinophilia-myalgia syndrome in some users (EMS). Some others believe that the EMS could have been brought on by an unintended contaminant that was present in certain 5-HTP products. However, there is not enough information from the scientific community to determine if EMS is brought on by 5-HTP, a contaminant, or another issue. Caution is needed when using 5-HTP until further information is gathered.

Special Precautions and Warnings

It is possible that taking 5-HTP at dosages of up to 400 mg per day for up to a year through oral consumption will not cause any adverse effects. Heartburn, stomach pain, nausea, vomiting, diarrhea, sleepiness, sexual dysfunction, and muscle dysfunction are the most typical adverse reactions that might occur when taking this medication.

It is possible that taking large dosages of 5-HTP, such as 6-10 grams on a daily basis, could be harmful. There has been a connection made between these doses and serious issues with the stomach as well as muscle spasms.

There is evidence that 5-HTP use may be linked to the development of a potentially fatal illness known as eosinophilia-myalgia syndrome in some users (EMS). Some others believe that the EMS could have been brought on by an unintended contaminant that was present in certain 5-HTP products. However, there is not enough information from the scientific community to determine if EMS is brought on by 5-HTP, a contaminant, or another issue.

Caution is needed when using 5-HTP until further information is gathered. Concerning pregnancy and nursing, there is not enough trustworthy information available to determine whether or not it is safe to use 5-HTP during pregnancy or while nursing. To be on the safe side, you should avoid using it.

Children: It is possible that giving children the supplement 5-HTP orally at the recommended doses will not cause them any harm. A daily dose of up to 5 mg/kg of 5-HTP appears to be safe for use in children younger than 12 years old for a period of up to three years.

5-HTP has been shown to have an effect on serotonin, a molecule found in the brain. A number of the medications that are taken during surgery can also have an effect on serotonin. Taking 5-HTP prior to surgery may cause an excessive amount of serotonin to be produced in the brain, which can lead to a variety of significant adverse effects, including anxiety, trembling, and cardiac difficulties. Patients should be instructed to discontinue taking 5-HTP at least two weeks before their scheduled surgery.

Interactions

Interaction that is Not Overbearing

Take precautions when using these two together.

Carbidopa (Lodosyn) has an effect on 5-hydroxytryptophan (5-HTP).

5-HTP has the ability to influence the brain. Carbidopa is also capable of having an effect on the brain. When 5-HTP is used with carbidopa, the probability of experiencing substantial adverse effects, such as agitation, sped-up speech, and increased hostility, is significantly increased.

Interactions between sedative medicines, often known as CNS depressants, and 5-HTP

It’s possible that 5-HTP will make you sleepy and slow down your breathing. Sedatives are a class of drugs that can cause drowsiness as well as a slowing of the respiratory rate. Combining 5-HTP with drugs that cause sedation could lead to respiratory difficulties and/or an excessive amount of sleepiness.

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Interactions between serotonergic medications and 5-HTP

There is speculation that 5-HTP can boost serotonin, a neurotransmitter found in the brain. This effect can also be caused by certain drugs. It is possible that taking 5-HTP in conjunction with these drugs will result in an excessive increase in serotonin. It is possible that this will produce severe adverse effects, including issues with the heart, seizures, and vomiting.

Dosing

The typical dose range for adults using 5-HTP is between 150 and 800 milligrams per day. It is important to avoid taking very high amounts of 5-HTP, such as 6-10 grams on a daily basis, as this might lead to major adverse effects. Talk to a medical professional about your symptoms to get a recommendation on the appropriate dosage for your condition.