L-Arginine – Uses, Side Effects, Warnings, and More

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Overview

An amino acid known as L-arginine can be found in foods such as red meat, chicken, fish, and dairy products. It is essential for the production of proteins and is also utilised often in circulation.

Nitric oxide is a byproduct of the transformation of the amino acid L-arginine into nitric oxide. The release of nitric oxide causes blood arteries to dilate, which results in an increase in blood flow. Additionally, L-arginine has been shown to induce the release of other chemicals in the body, such as insulin and growth hormone. It is possible to make it in a laboratory, and it is utilised in dietary supplements.

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L-arginine is taken by patients suffering from chest pain and a variety of disorders related to blood flow, as well as erectile dysfunction, high blood pressure during pregnancy, and a dangerous condition known as necrotizing enterocolitis that affects premature infants (NEC). It is also utilised for the treatment of a great number of other illnesses; however, there is insufficient credible scientific data to support these other applications.

What Are the Benefits and Applications?

Possible Usefulness in Regards to

Chest pain (angina). People who suffer from angina may notice a reduction in their symptoms, as well as an improvement in their exercise tolerance and overall quality of life when they take L-arginine orally. However, it does not appear to assist in expanding the blood vessels that are constricted due to angina.

Erectile dysfunction (ED). People who have ED appear to have improved sexual function when they took between 2.5 and 5 grammes of L-arginine orally on a daily basis. It is possible that taking L-arginine in combination with drugs like sildenafil and tadalafil will produce better results than taking either L-arginine or the medication on its own.

Elevated levels of blood pressure. People who are healthy, people who have high blood pressure, and people who have somewhat high blood pressure with or without diabetes can all benefit from having their blood pressure lowered by taking L-arginine orally.

A severe intestinal condition that can affect newborns born prematurely (necrotizing enterocolitis or NEC). It has been shown that they lower the risk of this problem in premature infants by adding L-arginine to their formula.

Narrowing of the blood arteries results in inadequate blood flow to the extremities (peripheral arterial disease). People who have this problem benefit from increasing their blood flow by taking L-arginine either orally or intravenously for a period of up to eight weeks. However, continuing to use it for up to six months has no positive effect on either walking speed or distance. Only a trained medical professional should administer IV medications.

A condition that can occur during pregnancy and is characterised by elevated blood pressure and the presence of protein in the urine (pre-eclampsia). In pregnant women who have pre-eclampsia, receiving L-arginine through an IV can help lower their blood pressure. People who are at high risk for developing pre-eclampsia may benefit from taking L-arginine because it may lower their likelihood of developing the illness. Only a trained medical professional should administer IV medications. It is not entirely known whether or not ingesting L-arginine helps.

Having a pregnancy complicated by high blood pressure.

In pregnant women, receiving L-arginine by intravenous administration can help lower blood pressure. It is not known whether or not ingesting L-arginine lowers blood pressure during pregnancy; nevertheless, it may reduce the requirement for taking medications that lower blood pressure. Only a trained medical professional should administer IV medications.

It’s Possible That This Won’t Work for

A chronic illness affecting the kidneys (chronic kidney disease or CKD). In the majority of persons who have chronic kidney disease (CKD), using L-arginine either orally or intravenously does not enhance kidney function.

Poor cholesterol levels. Consuming L-arginine through the digestive system does not contribute to a reduction in cholesterol levels.

Heart attack. Consuming L-arginine through the digestive system does not appear to help prevent heart attacks. It also does not appear to be helpful in treating a heart attack after it has already taken place. In point of fact, there is some cause for concern that L-arginine may be detrimental for those who have recently suffered a heart attack. If you have recently recovered from a heart attack, you should avoid taking L-arginine.

Tuberculosis. Consuming L-arginine through the digestive system in conjunction with the conventional treatment for tuberculosis does not appear to be of any use in reducing the severity of symptoms or curing the infection.

Healing of a wound Consuming L-arginine through the digestive system does not appear to hasten the healing of wounds.

L-arginine is being considered for use in a variety of additional contexts; however, there is an insufficient quantity of trustworthy data to determine whether or not this would be beneficial.

Adverse Reactions

L-arginine, when taken orally and for a limited amount of time, is likely to be safe for the vast majority of people. It’s possible that you could get some unpleasant side effects like stomach aches, bloating, diarrhoea, and low blood pressure if you take it.

When taken topically for a limited amount of time, L-arginine is likely to be safe for the vast majority of people. It is also possible that it is safe when used in toothpaste for a limited amount of time.

When used for only a short period of time, L-arginine could be safe for the vast majority of people to inhale.

Important Safety Instructions and Cautionary Notes

L-arginine, when taken orally and for a limited amount of time, is likely to be safe for the vast majority of people. It’s possible that you could get some unpleasant side effects like stomach aches, bloating, diarrhoea, and low blood pressure if you take it.

When taken topically for a limited amount of time, L-arginine is likely to be safe for the vast majority of people. It is also possible that it is safe when used in toothpaste for a limited amount of time.

When used for only a short period of time, L-arginine could be safe for the vast majority of people to inhale. L-arginine may not pose a risk to the mother and baby when taken orally for a limited amount of time during pregnancy. There is little information regarding the use of L-arginine over an extended period of time during pregnancy. Avoid using it for an extended period of time as a precaution.

It is not possible to determine whether or not it is safe to take L-arginine while breastfeeding due to a lack of sufficient and accurate information. To be on the safe side, you should avoid using it.

When administered orally, like in the form of toothpaste, or breathed, L-arginine may be safe for usage in children under certain conditions.

Guanidinoacetate methyltransferase deficiency (GAMT) is a hereditary disorder in which affected individuals are unable to convert arginine and other compounds with a similar chemical structure into creatine. Steer clear of L-arginine pills if you want to avoid the potential difficulties that come with this illness.

L-arginine may raise the chance of death following a recent heart attack, particularly in older adults. This is especially true in cases when a heart attack occurred recently. Do not use L-arginine if you have had a heart attack within the past few months.

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People who suffer from kidney illness have been shown to see an increase in their potassium levels after taking L-arginine. This has, in some instances, led to a potentially life-threatening cardiac irregularity.

L-arginine may cause problems with maintaining a healthy blood pressure level during and after surgical procedures. Put an end to your L-arginine consumption at least two weeks before your scheduled surgical procedure.

What are the interactions?

Interaction that is Not Overbearing

Take precautions when using these two together.

L-ARGININE with the medications used to treat high blood pressure (antihypertensive drugs) can have an adverse interaction.

L-arginine has been shown to reduce high blood pressure. Combining L-arginine consumption with medicine intended to decrease blood pressure could result in an abnormally low blood pressure reading. Always keep a tight eye on your blood pressure.

Sildenafil (brand name Viagra) has been shown to interact with L-ARGININE.

Sildenafil is capable of bringing blood pressure down. Additionally, L-arginine has been shown to reduce blood pressure. If you take sildenafil and L-arginine at the same time, there is a possibility that your blood pressure will drop to an unsafe level. However, the majority of people appear to have no issues while taking both of these medicines together.

ACE inhibitors, which are medications used to treat high blood pressure, are known to interact with L-ARGININE.

L-arginine has been shown to reduce high blood pressure. Combining L-arginine consumption with medicine intended to decrease blood pressure could result in an abnormally low blood pressure reading. Always keep a tight eye on your blood pressure.

Angiotensin receptor blockers, which are medications used to treat high blood pressure, are known to interact with L-ARGININE.

L-arginine has been shown to reduce high blood pressure. Combining L-arginine consumption with medicine intended to decrease blood pressure could result in an abnormally low blood pressure reading. Always keep a tight eye on your blood pressure.

L-ARGININE has an effect on how medications that slow blood clotting (anticoagulant and antiplatelet medicines) work in the body.

L-arginine has been shown to inhibit the coagulation of blood. It is possible that the risk of bruising and bleeding will rise if L-arginine is taken in conjunction with other drugs that also reduce the coagulation of blood.

L-ARGININE can have an effect on the way diabetic medications (antidiabetes medicines) work in the body.

L-arginine has been shown to reduce sugar levels in the blood. It is possible that using L-arginine in conjunction with diabetes medication will result in an unsafely low blood sugar level. Keep a tight eye on your blood sugar levels.

Isoproterenol (also known as Isuprel) has an effect on L-ARGININE.

L-arginine appears to have a hypotensive effect on blood pressure. Isoproterenol is a medication that is taken in order to bring the user’s blood pressure down. If you take isoproterenol combined with L-arginine, you run the risk of experiencing dangerously low blood pressure.

The potassium-sparing diuretics known as water pills have been shown to interact with L-ARGININE.

It’s possible that taking L-arginine will make your body produce more potassium. It’s possible that taking certain “water tablets” could potentially cause a rise in potassium levels in the body. It is possible that an unsafely high level of potassium will develop in the body if L-arginine is taken concurrently with some “water pills.”

A Slightly Interacting Party

Take caution when using these two together.

There is a reaction between testosterone and L-ARGININE.

There is some evidence that L-arginine can raise testosterone levels. However, it is unclear if this should be a major issue. People who take testosterone should exercise caution until more is learned about the possibility of an interaction between the two substances.

Dosing

Adults have been known to take L-arginine in amounts ranging from 1.5 to 24 grammes by mouth on a daily basis, for a period of time that can last up to 18 months. Additionally, it is sometimes utilised in the production of gels and creams. Talk to a medical professional if you want to find out which kind of treatment or dosage would be most appropriate for a particular problem.