Berberine – Uses, Side Effects, Warnings, and More

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Overview

There are a number of plants that contain the chemical berberine, including European barberry, goldenseal, goldthread, Oregon grape, Phellodendron, and tree turmeric.

The molecule known as berberine has a taste similar to that of bitter almonds and a yellow appearance. It is possible that it will assist strengthen the heartbeat, which may be beneficial to individuals who suffer from certain heart diseases. It is also possible that it will destroy bacteria, assist in the regulation of how the body uses sugar in the blood, and assist in the reduction of edema.

Diabetes, high blood pressure, and abnormally high levels of cholesterol or other lipids in the blood are the conditions for which berberine is most frequently prescribed to patients. Additionally, it is utilized in the treatment of burns, canker sores, liver illness, and a multitude of other conditions; however, the majority of these applications are not supported by solid scientific data.

Uses & Effectiveness

Possible Usefulness in Regards to

Canker sores. Canker sores can have their discomfort, redness, and oozing reduced, as well as their size, if you use a gel that contains berberine.

Diabetes. People who have diabetes and take berberine orally may have a moderately significant reduction in their blood sugar levels.

An abnormally high concentration of cholesterol or other lipids (fats) in the blood (hyperlipidemia). People who have high cholesterol levels could benefit from taking berberine orally, either on its own or in combination with other components, in order to bring their total cholesterol, low-density lipoprotein (“bad”) cholesterol, and triglyceride levels down.

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Elevated levels of blood pressure. People who have high blood pressure benefit more from taking amlodipine in combination with berberine in the amount of 0.9 grams per day taken orally, as this combination lowers blood pressure more effectively than amlodipine taken on its own.

A hormonal condition that results in the development of cysts and enlarged ovaries (polycystic ovary syndrome or PCOS). People who have PCOS and take berberine orally may see a reduction in their blood sugar levels, an improvement in their cholesterol and triglyceride levels, a reduction in their testosterone levels, and a reduction in their waist-to-hip ratio.

There is an interest in employing berberine for a variety of additional functions; however, there is insufficient trustworthy information to determine whether or not this could be beneficial.

Side Effects

Berberine, when taken in this manner, is likely to be safe for the vast majority of adults. It has been successfully used in doses as high as 1.5 grams per day for a period of 6 months. The most common adverse effects include gastrointestinal distress, gas, diarrhea, and constipation.

When taken topically for a limited amount of time, Berberine may not cause any adverse effects in the majority of adult patients.

Special Precautions and Warnings

Berberine, when taken in this manner, is likely to be safe for the vast majority of adults. It has been successfully used in doses as high as 1.5 grams per day for a period of 6 months. The most common adverse effects include gastrointestinal distress, gas, diarrhea, and constipation.

When taken topically for a limited amount of time, Berberine may not cause any adverse effects in the majority of adult patients. Ingestion of berberine when pregnant is probably not a good idea due to the potential for birth defects. Berberine is able to pass through the placenta, which may be harmful to the developing embryo. A form of brain injury known as kernicterus has been observed in newborn newborns who have been exposed to berberine.

If you are breastfeeding, you should probably avoid using berberine because it could be harmful to your baby. Berberine has the potential to be harmful to newborns if it is passed on to them through the mother’s breast milk.

Berberine should probably not be given to infants who have just been born. Kernicterus is an extremely uncommon form of brain injury that can take place in neonates who have excessive jaundice and is brought on by this condition. There is an insufficient amount of trustworthy data to determine whether or not berberine is safe for use in older children.

Neonates who have high levels of the chemical bilirubin in their blood Bilirubin is a byproduct of the breakdown of old red blood cells and can be seen in high levels in infants. In a typical situation, the liver will dispose of it. There is a possibility that berberine will slow down the rate at which the liver eliminates bilirubin. This can result in issues with the brain, particularly in infants who already have high amounts of bilirubin in their blood. Avoid using.

Interactions

Significant Participation

Do not combine these medications in any way.

There is an interaction between the medications cyclosporine (Neoral, Sandimmune) and berberine.

The rate at which cyclosporine is broken down in the body may be slowed down by berberine. It’s possible that this will make the cyclosporine’s effects and adverse effects worse.

Interaction that is Not Overbearing

Take precautions when using these two together.

Medications that are metabolized by the liver, often known as substrates for the cytochrome P450 3A4 enzyme, interact with berberine.

The liver is responsible for the transformation and breakdown of certain drugs. There is a possibility that berberine will alter the rate at which the liver breaks down certain drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

Berberine is known to interact with a number of medications, including those known as anticoagulants and antiplatelet medicines.

Berberine has been shown to inhibit the coagulation of blood. It is possible that the risk of bruising and bleeding will rise if you take berberine in conjunction with other drugs that also delay blood coagulation.

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Berberine has an interaction with diabetic medications, often known as anti-diabetes medicines.

There is some evidence that berberine can bring down blood sugar levels. Berberine, when taken in conjunction with diabetes medicine, may result in dangerously low blood sugar levels. Keep a tight eye on your blood sugar levels.

Antihypertensive medicines, which are prescribed to treat high blood pressure, are known to interact negatively with berberine.

There is some evidence that berberine can lower blood pressure. When combined with other drugs that lower blood pressure, berberine may cause the patient’s blood pressure to drop to an unsafe level. Always keep a tight eye on your blood pressure.

Berberine has a negative interaction with sedative drugs, often known as CNS depressants.

Berberine has been shown to cause drowsiness as well as a slowing of the respiratory rate. Sedatives are a class of drugs that can cause drowsiness as well as a slowing of the respiratory rate. It is possible that using sedative drugs along with berberine will result in breathing difficulties and/or excessive tiredness.

Medications that are metabolized by the liver, also known as substrates for the cytochrome P450 2C9 enzyme, interact with berberine.

The liver is responsible for the transformation and breakdown of certain drugs. There is a possibility that berberine will alter the rate at which the liver breaks down certain drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

Medications that are metabolized by the liver, often known as substrates for the cytochrome P450 2D6 enzyme, interact with berberine.

The liver is responsible for the transformation and breakdown of certain drugs. There is a possibility that berberine will alter the rate at which the liver breaks down certain drugs. It is possible that the effects and side effects of these medications will vary as a result of this.

There is an interaction between dextromethorphan (which is found in Robitussin DM and other products) and berberine.

There is a possibility that berberine will slow down the rate at which the body metabolizes dextromethorphan. It’s possible that this will make the effects and the negative side effects of dextromethorphan worse.

There is a drug interaction between losartan (Cozaar) and berberine.

Losartan is functional only after being activated by the liver. Berberine may slow down the rate at which the body activates losartan, which may lead to a reduction in the effectiveness of the drug.

There is an interaction between Midazolam (Versed) and BERBERINE.

Midazolam is eliminated from the body through the process of breakdown. Berberine has the ability to slow down the rate at which it is metabolized in the body. It’s possible that this will make the effects and side effects of the midazolam much worse.

Nembutal, also known as pentobarbital, has a reaction with berberine.

Pentobarbital is a drug that has the potential to make a person feel sleepy. Berberine has been shown to cause tiredness and sleepiness in some people. The combination of berberine and pentobarbital could result in an excessive amount of sleepiness.

There is an interaction between tacrolimus (Prograf) and berberine.

The liver is responsible for clearing tacrolimus from the body. It’s possible that berberine will inhibit the body’s capacity to eliminate tacrolimus. It’s possible that this will make tacrolimus’ effects and side effects more pronounced.

There is a drug interaction between Metformin (Glucophage) and BERBERINE.

There is a possibility that berberine will cause an increase in the amount of metformin found in the body. It’s possible that this will make its effects and adverse effects worse. It appears that this interaction takes place when berberine is consumed approximately two hours before metformin. It does not appear that taking metformin and berberine at the same time will result in an increase in the amount of metformin found in the body.

Dosing

Adults have been known to take berberine in amounts ranging from 0.4 to 1.5 grams by mouth, once or twice daily, for up to two years. Eye drops and gels containing berberine have also been manufactured. Talk to a medical professional about your symptoms to find out what kind of treatment and dosage would work best for your particular problem.